Myocardin immunohistochemistry index is associated with clinical prognosis in nasopharyngeal carcinoma: a clinical practice-based cohort study

Purpose: Recent findings have implicated the role of myocardin re-expression in carcinogenesisHowever, clinical functions nasopharyngeal carcinoma (NPC) is not known yet. The purpose for cohort research was to investigate whether level may predict prognosis NPC patients.Methods: 148 patients were recruited from September, 2005 2011 with median follow-up time 4.5 years a practice setting. At study entry these determined using immunohistochemistry (IHC) and additional 20 normal tissues included as control. Two-sample t-test used compare mean reexpression levels Chi-square test comparing tumour recurrence rate. Logistic regression analysis local control rate, log-rank test, Kaplan-Meier estimates Cox proportional hazard model disease-free survival overall survival.Results: Myocardin IHC index significantly downregulated samples than normalnasopharyngeal (mean ± standard deviation, 61.2 ±31.5 vs. 109.9 ±73.6, P= 0.009). However, among observed roughly V-shaped change according Tumour T-stage (P=0.067); meanwhile higher associated more rate (High Low: 21.6% 8.1%; P=0.021). equally showed high an independent risk factor regardless adjustments [High unadjusted Odds Ratio (OR) 0.320, 95% confidence interval (CI): 0.117 0.871; P=0.026]. Moreover, marginal but significant increase adjusted Hazard (HR) 1.760, CI: 0.981 3.158; log-rank: P=0.129]. A less obvious trend regard [adjusted HR 1.409, 0.715 2.77; P=0.745].Conclusion: results suggested that could be potential clinically prognostic intermediate biomarker routine practice. Large well-designed studies involving over needed.